What is CBDA?

There are over 400 compounds found in the cannabis plant including what are known as ‘cannabinoids’. This group of compounds interact directly with the human body’s cannabinoid receptors. These receptors are effectively binding sites for cannabinoids and are part of what is known as the ‘endocannabinoid system’.

Two well-known cannabinoids are Tetrahydrocannabinol (THC) and Cannabidiol (CBD). CBD in particular has been gaining traction in the health and wellness market as countries begin to relax their laws around the use of this compound which clinical research has shown to have anti-anxiety and pain-relieving properties.

CBDA (Cannabidiolic Acid) is known as a carboxylic acid. This means its structure contains a carboxyl group comprising one carbon, one hydrogen, and two oxygen atoms, commonly expressed as COOH. When you expose this molecule to high temperatures, this group breaks up to form carbon dioxide and hydrogen. What’s left is CBD.

In short, CBDA is the raw form of CBD. It turns into CBD when heated. Since most extraction processes require heat, it is not easy to extract the raw CBDA compound from the plant into a concentrate for human consumption. For a long time researchers ignored CBDA because they saw it as inert: requiring decarboxylation (heating) in order to unlock its potential in the form of CBD.  However, that all changed about ten years ago when a research team compared the molecular structures of CBDA with nonsteroidal anti-inflammatory drugs (NSAIDs) commonly used to treat inflammation and found their chemical structures remarkably similar. Since then CBDA has been stealing a lot of attention from its cannabis cousins largely due to its greater bioavailability: meaning the body can metabolise the compound with less effort and in less time. 


What Is the Difference Between CBD and CBDA?

Up until 2019, CBDA’s use in therapeutic treatments was problematic because of its inherent instability: it naturally decarboxylates into CBD. However, our partners at Verve Dynamics Lesotho have identified a method to stabilise CBDA, which led to Botanican’s range of CBDA products. We believe this is a game-changer as recent research has found CBDA to be significantly more powerful than CBD for the treatment of anxiety, inflammation and nausea.

CBDA has greater bioavailability compared to CBD (in fact, scientists have shown that CBDA has 100 times the affinity for the 5-HT receptors compared to CBD), making it quicker-acting and more powerful than CBD alone. While most cannabinoids bind directly with the CB1 and CB2 receptors, CBDA interacts directly with serotonin receptors, much like selective serotonin reuptake inhibitors (SSRIs) which are used to treat depression. This same receptor affinity suggests that the potential for CBDA as a plant-based anti-depressant medication deserves serious attention.


Links to articles and research papers:

In vivo studies have found that CBDA has potential for treating:

May 10, 2022

SARS-CoV-2 and its variants, which cause COVID-19

May 13, 2020


Cannabidiol disrupts conditioned fear expression and cannabidiolic acid reduces trauma-induced anxiety
October 13, 2018


Acute oral cannabidiolic acid methyl ester reduces depression-like behavior in two genetic animal models of depression
September 13, 2015

Acute Nausea and Anticipatory Nausea

Effect of combined doses of Δ9-tetrahydrocannabinol (THC) and cannabidiolic acid (CBDA) on acute and anticipatory nausea
November 13, 2012

Breast Cancer

Cannabidiolic acid, a major cannabinoid in fiber-type cannabis, is an inhibitor of MDA-MB-231 breast cancer cell migration
September 12, 2008

Inflammation and Pain

Cannabidiolic acid as a selective cyclooxygenase-2 inhibitory component in cannabis

The 'Entourage Effect'

Our full spectrum CBDA products contain all cannabinoids, terpenes, and flavonoids present in the cannabis plant. The entourage effect is the theory that all the compounds in cannabis including cannabinoids, terpenes, and flavonoids work together to enhance the overall effect on the body. To put it simply, the whole is greater than the sum of its parts. The way the compounds interact synergistically with each other is a crucial part of the therapeutic effect. For this reason, all our products are formulated from a whole plant extraction, meaning we maintain the integrity of the plant’s unique cannabinoid and terpene profile, bringing you ‘full spectrum’ wellness as nature intends.


Selecting the right strength product option

Botanican’s CBDA oil comes in three strengths: 600mg, 1200mg and 3000mg specifying the total combined amount of CBD and CBDA (1:1 ratio) in each bottle. The capsules come in 20mg and 40mg options. The amount of CBDA required depends on your ailment, weight, and endocannabinoid system. Begin with a low dose and increase it until the desired effect is achieved.


Recommended dosage for supplementing general health and wellbeing.


Recommended dosage for people whose systems are receptive to cannabinoids, to alleviate anxiety and nausea.


Recommended dosage for those whose systems are receptive to cannabinoids, to alleviate inflammation and pain.


Cold ethanol extraction

The key to creating Botanican’s signature CBDA products.


See our lab results

All our products are tested by an independent laboratory.


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